|
rs932546861
|
ADH1B;ADH1C
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the G78stop mutation was identified in 4 (10.0%) of 40 Caucasian index cases with PD with mainly hereditary forms of the disorder.
|
15642852 |
2005 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.
|
28610454 |
2018 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms.
|
27172571 |
2016 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected.
|
22325912 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample.
|
25372623 |
2015 |
|
rs698
|
ADH1B;ADH1C
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation |
BEFREE |
The results showed strong evidence of association between ADH1C Ile350Val (rs698, formerly ADH1C *1/*2) and alcohol dependence (AD) and abuse in the combined studies.
|
22476623 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
The results indicate that ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians.
|
22675424 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
The results indicate that ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians.
|
22675424 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Malignant neoplasm of esophagus
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a population-based case-control study with 858 EC cases and 1,081 controls conducted in Jiangsu Province, China, we aimed to provide further information on the association of ADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) polymorphisms with EC in a Chinese population.
|
22930414 |
2013 |
|
rs698
|
ADH1B;ADH1C
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Lack of the ADH1B rs1229984 protective allele was significantly associated with consumption- and AUD-related phenotypes (OR = 1.77 for AUD; OR = 1.83 for risk drinking), while lack of the ADH1C rs698 protective allele was significantly associated with AUD-related phenotypes (OR = 2.32 for AUD).
|
23895337 |
2013 |
|
rs698
|
ADH1B;ADH1C
|
Esophageal carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a population-based case-control study with 858 EC cases and 1,081 controls conducted in Jiangsu Province, China, we aimed to provide further information on the association of ADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) polymorphisms with EC in a Chinese population.
|
22930414 |
2013 |
|
rs698
|
ADH1B;ADH1C
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
|
22500060 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Pancreatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Numerous studies have focused on the relationship be-tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent.
|
26634490 |
2015 |
|
rs698
|
ADH1B;ADH1C
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
|
22500060 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Liver diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.
|
22048268 |
2011 |
|
rs698
|
ADH1B;ADH1C
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
There were nonstatistically significant associations between rs693482 C-->T and rs698 A-->G mutations and prevalent CVD among current drinkers (lower CVD prevalence with minor allele) but not among nondrinkers in whom the minor allele was associated with a trend toward higher CVD prevalence (p values for interaction are 0.16 for rs1693482 and 0.52 for rs698).
|
16018848 |
2005 |
|
rs698
|
ADH1B;ADH1C
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
The alcohol dehydrogenase 1C(rs698) genotype and breast cancer: a meta-analysis.
|
22652248 |
2015 |
|
rs698
|
ADH1B;ADH1C
|
Esophageal Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a population-based case-control study with 858 EC cases and 1,081 controls conducted in Jiangsu Province, China, we aimed to provide further information on the association of ADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) polymorphisms with EC in a Chinese population.
|
22930414 |
2013 |
|
rs698
|
ADH1B;ADH1C
|
Nicotine Dependence
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2).
|
24505444 |
2014 |
|
rs698
|
ADH1B;ADH1C
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The alcohol dehydrogenase 1C(rs698) genotype and breast cancer: a meta-analysis.
|
22652248 |
2015 |
|
rs698
|
ADH1B;ADH1C
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs698
|
ADH1B;ADH1C
|
Alcohol abuse
|
|
0.010 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
rs698
|
ADH1B;ADH1C
|
Drug abuse
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed strong evidence of association between ADH1C Ile350Val (rs698, formerly ADH1C *1/*2) and alcohol dependence (AD) and abuse in the combined studies.
|
22476623 |
2012 |